After confirming the presence of TMEM97 together with Aβ in synapses of Alzheimer’s cases, and given the ability of Sigma-2 receptors to displace Aβ from neuronal synapses [27], we assessed the proximity of the immunoreactivity of TMEM97 with that of Aβ in synapses of AD cases by FRET. This evidence concerns the gene TMEM97 and Alzheimer disease.