LGR5 negativity has been associated with inflamed tumours, and elegant recent work has demonstrated how stem cells and, indeed lesions overall, can shift between these LGR5-positive CBC and LGR5-negative ANXA1+ regenerative stem cell (RSC) states, defined as plasticity, as they adapt and respond to changes in microenvironmental conditions (Fig. 4) [46]. Here, LGR5 is linked to neoplasm.