In addition, the expression level of genes involved in the signaling pathways of the JAK-STAT and Toll-like receptor in convalescents was lower than in COVID-19 naive individuals before and after vaccination (Fig. 5A), indicating that even after vaccination, part of the dysfunctional immune regulator pathways disrupted by SARS-CoV-2 infection was not fully restored. The gene discussed is SOAT1; the disease is COVID-19.