In contrast to the significant differences in infectious titers detected for the p100/Jc1 chimera harboring adaptive mutations in Core to NS2 proteins upon infection of Huh-7 cells (Fig. 3C), the number of infectious particles released to the cell culture supernatant remained unaltered upon transfection of viral RNA into Lunet N#3 cells when compared to Jc1 (Fig. 3E). The gene discussed is LZTR1; the disease is infection.