Numerous hypermethylated genes, including BMP3, CDKN2A, FGF5, hMLH1, MGMT, NDRG4, NPY, PDX1, SDC2, SEPT9, SFRP2, TFPI2, and VIM, have been analyzed in fecal DNA for CRC early detection2,4 (Table 1). Here, SEPTIN9 is linked to colorectal carcinoma.