In addition, the NMPA in China has approved several novel multigene methylation stool test kits for the detection of CRC, including SDC2/TFPI2, SDC2/SFRP2, SEPT9/SDC2/BCAT1, and SDC2/NPY/FGF5/PDX1 (Table 1). This evidence concerns the gene SFRP2 and colorectal carcinoma.