Numerous hypermethylated genes, including BMP3, CDKN2A, FGF5, hMLH1, MGMT, NDRG4, NPY, PDX1, SDC2, SEPT9, SFRP2, TFPI2, and VIM, have been analyzed in fecal DNA for CRC early detection2,4 (Table 1). This evidence concerns the gene SDC2 and colorectal carcinoma.