To date, several potential blood-based DNA methylation biomarkers have been identified for CRC detection, including BCAT1, BMP3, C9orf50, CDKN2A, CLIP4, KCNQ5, MLH1, NDRG4, PRIMA1, SDC2, SEPT9, SFRP2, and VIM2,4 (Table 1). This evidence concerns the gene BMP3 and colorectal carcinoma.