The main findings indicate that higher MTHFD2 expression is associated with a poorer prognosis in breast cancer, specifically in TNBC. The study also explores the potential link between MTHFD2 and ferroptosis, suggesting that MTHFD2 may play a role in regulating this process in TNBC cells. This finding opens avenues for further understanding the molecular mechanisms underlying TNBC prognosis. This evidence concerns the gene MTHFD2 and breast cancer.