KRT19 and neoplasm: The presence of Ck19 in the CTCs increases the probability of detecting metastasis and regional recurrence in OSCC patients [21]. Saliva has a hopeful association with OSCC planning and monitoring; new studies about the use of circulating tumor DNAs, extracellular vesicles, microRNAs, and CTC as saliva biomarkers in OSC routine practice may aid in the growth of consistent strategies for initial tumor detection in lesions, promote prevention, and assist the development of therapy; it will enhance clinical outcome.