Complexin 2, a protein involved in synaptic vesicle fusion and whose dysregulated expression is associated with a number of cognitive disorders (Brose, 2008; Hass et al., 2015), was more highly expressed in males compared to females in both age groups, and this gene was also significantly downregulated with aging in both sexes (female vs. male: young log2FC = −0.16, aged log2FC = −0.21; aged vs. young: male log2FC = −0.16, female = −0.21). The gene discussed is CPLX2; the disease is Cognitive impairment.