MIAT and breast cancer: Gomafu expression has been shown to be regulated by estrogen in breast cancer cells (Li et al., 2018) and by synaptic activity in neurons (Barry et al., 2014; Zakutansky and Feng, 2022), and although many alternatively spliced Gomafu isoforms have been identified, little is known about their distinct functions (Zakutansky and Feng, 2022).