This includes the presence of TAR DNA-binding protein 43 (TDP-43) cytoplasmic inclusions within the central nervous system (Neumann et al., 2006; Lillo and Hodges, 2009), which was considered as a potential biomarker for ALS/FTD (Majumder et al., 2018). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.