We have also shown that GSK3β plays a role in the acquisition of resistance to gemcitabine in resistant pancreatic cancer cell clones derived from BxPC-3[124] [Figure 2], via impairing the functional interaction between the Rb tumor suppressor protein and pro-oncogenic E2 transcription factor (E2F)1[179]. Here, GSK3B is linked to familial pancreatic carcinoma.