Our previous studies on gemcitabine-unresponsive pancreatic cancer and temozolomide-resistant glioblastoma cells have indicated that GSK3β enhances tumor cell migration and invasion via the focal adhesion kinase (FAK), Rac1, and c-Jun N-terminal kinase (JNK)-mediated pathway[169,183]. This evidence concerns the gene GSK3B and familial pancreatic carcinoma.