TLR3 and neoplasm: Neuroblastoma plasticity defines two adrenergic and mesenchymal epigenetic cell states associated with inactive or active responsiveness to inflammatory sensing, including HLA class I upregulation by the TLR3-activating double-stranded (ds)RNA mimetic poly (I:C) (93), and immune response genes are indeed epigenetically silenced by the PRC2 complex in adrenergic tumor cells (94).