In HGG, the B*44:02 and DRB1*01:01 alleles were not detected and other alleles were specifically under- (B*08:01, DRB1*15:01, DQA1*01:01, DQB1*06:02) or overrepresented (DRB1*07:01, DQB1*02:02) in GBM but not in other HGG; the DQA1*01:01 allele was actually overrepresented in non-GBM. This evidence concerns the gene HLA-DRB1 and glioblastoma.