However, recurrent gene fusions in pediatric cancers rarely involve these regions, with only two cases validated in 48 tumors from the MOSCATO-01 cohort (two translocations t (6, 6) and (6, 17) generating GPANK1::ABHD16A and PPP1R18::FXR2 gene fusions in eRMS and osteosarcoma cases, respectively) (3, 60). This evidence concerns the gene PPP1R18 and osteosarcoma.