HLA-DRB1 and multiple sclerosis: However, the DRB1*04:08 allele has been previously associated with other autoimmune conditions and associated clinical phenotypes, namely anti-citrullinated protein antibody-positive and childhood Rheumatoid Arthritis (RA), clinical severity of RA and anti-drug antibody development in Multiple Sclerosis patients under Interferon beta treatment (48–50).