To explain this effect, at the molecular level in Rizza et al. (61), night workers have a high REV-ERBα/BMAL1 mRNA ratio (possible chronic circadian misalignment due to exposure to prolonged artificial light) associated with a significant correlation between HbA1c and the expression of IL-1β RNA in leukocytes, even with values of glycemic parameters within reference standards, very common in low chronic inflammation associated with the risk of T2DM (61). This evidence concerns the gene NR1D1 and type 2 diabetes mellitus.