BMAL1 and type 2 diabetes mellitus: To explain this effect, at the molecular level in Rizza et al. (61), night workers have a high REV-ERBα/BMAL1 mRNA ratio (possible chronic circadian misalignment due to exposure to prolonged artificial light) associated with a significant correlation between HbA1c and the expression of IL-1β RNA in leukocytes, even with values of glycemic parameters within reference standards, very common in low chronic inflammation associated with the risk of T2DM (61).