However, our previous research revealed that the depletion of CD8+ T, natural killer T (NK-T), and natural killer (NK) cells in ALS model mice with the C57BL/6 genetic background from the onset of age had no impact on survival times,25 indicating that environmental factors derived from peripheral immune cells and/or infiltrating immune cells, with the exception of CD8+ T, NK-T, and NK cells, may affect the course of the disease by regulating microglial heterogeneity, survival, and DAM induction in ALS model mice. Here, CD8A is linked to amyotrophic lateral sclerosis.