The expression levels of neuroprotective genes Igf1, Gpnmb, Lgals3, and Mif, which have been previously reported in ALS model mice,28,29,30,31,32,33 were found to be enriched in the overlapped 153 genes (Figure S8D) as well as Csf1 and Tnfaip3. We found that the induction of Csf1-encoded M-CSF was limited in G93AL(Balb) microglia (Figures 3A−3D). This evidence concerns the gene GPNMB and amyotrophic lateral sclerosis.