CASP3 and cancer: CK2 has been shown to mediate anti-apoptotic pathway by protecting substrates from caspase-3-mediated proteolysis,38,43 and CX-4945 was previously reported to induce apoptotic cell death in cancer cells lines such as PC3 prostatic adenocarcinoma,25 B-ALL, T-ALL,44,45 H1299, Calu-1, and H358.46