Metabolic enzymes such as phosphoserine aminotransferase (PSAT1), UDP-N-acetylglucosamine pyrophosphorylase 1 (UAP1), and methylenetetrahydrofolate deshydrogenase/cyclohydrolase (MTHFD2), that are highly expressed in a wide range of tumors and associated with poor prognosis in tumor progression,67,68,69,70,71 were significantly down regulated by AB668 when compared to CX-4945. Here, MTHFD2 is linked to neoplasm.