Altogether, these results not only provide useful knowledge about the biology of trout as well as strategy to improve current PBD formulations required to sustain carnivorous fish production from the aquaculture field, but, more broadly, they also offer new models and open new avenue related to various pathologies such as hypercholesterolemia, diabetes, and inherited rare diseases caused by AAT mutations. The gene discussed is SERPINA1; the disease is familial hypercholesterolemia.