(2011) used the replication-competent avian leukosis virus with splice acceptor/Tv-a (RCAS/Tv-a) system to introduce different BRAF constructs into Nestin-expressing neural progenitor cells and found that while the full-length BRAF V600E did not induce glioma in vivo, the transgenic expression of only the BRAF V600E kinase domain in the cerebral hemispheres was sufficient to induce PA formation (65). The gene discussed is BRAF; the disease is central nervous system cancer.