POMC and Cushing syndrome due to macronodular adrenal hyperplasia: Cushing’s syndrome can be divided into two main aetiological groups, namely ACTH-dependent and ACTH-independent CS: the first group comprises CD and ectopic ACTH syndrome, whereas the second one comprises adrenal cortical neoplasms, both benign and malignant, and adrenocortical hyperplasia.