We next demonstrated that low expression of TMEM219 in insulinoma-derived cells was associated with detectable expression of the endogenous miR-129-2, which was also highly expressed in the insulinoma cell line INS-1, thereby confirming that TMEM219 expression is under the control of miR-129-2 also in prone-to-proliferate beta cells (Figure 3H). This evidence concerns the gene TMEM219 and pancreatic insulinoma.