Based on the results of the univariate Cox analysis, variables such as age, BMI, smoking, hypertension, diabetes, Hb, CRP, Alb, creatinine, BUN, uric acid, PT, D-dimer, potassium, APACHE II score, SOFA score, vasoactive drug, CRRT, invasive ventilation, and incidence of AKI were included in the multivariate analysis. The gene discussed is CRP; the disease is acute kidney injury.