After adjusting for confounding factors, such as age, sex, hypertension, diabetes, WBC, CRP, Alb, creatinine, BUN, uric acid, PCT, D-dimer, and lactate level, both the middle and high N/LP groups showed a greater risk of ICU mortality with a 2.451/3.830-fold increase (95%CI: 1.273, 4.718; 95%CI: 1.934, 7.585, respectively) compared to the low NLR group. The gene discussed is CRP; the disease is diabetes mellitus.