They showed that the codelivery of epirubicin and melittin by using a mixture of mucin 1-dimer aptamer-CCNs-melittin complex and micin 1-dimer aptamer-CCNs-epirubicin complex exerted significant synergistic cytotoxicity in murine colon cancer C26 cell line and MCF-7 cells. This evidence concerns the gene MUC1 and malignant colon neoplasm.