After establishing productive XVir-N-31-infection with consequent EwS cell lysis and de novo production of infectious particles, EwS-redirected CD8+ T cells retrovirally transduced to express an HLA-A*02:01-restricted TCR recognizing the nonameric peptide CHM1319 (VIMPCSWWW) derived from the source protein Chondromodulin-1 were tested in combination with XVir-N-31. The gene discussed is CNMD; the disease is infection.