FGF19/FGFR‐mediated ETV4 increases the expression of PD‐L1 and chemokine CCL2 in HCC, leading to the accumulation of tumor‐associated macrophages (TAMs) and MDSCs, suppression of CD8+ T cell activity, and promotion of HCC metastasis.266. This evidence concerns the gene CD8A and hepatocellular carcinoma.