For instance, some TCM-based bioactive compounds might enhance VDR gene expression or antagonize VDR receptor, thereby positively or negatively influencing the biological processes regulated by VDR and potentially ameliorating the symptoms or progression of VDR-dependent diseases like bone diseases, neurodegenerative diseases, etc. (Ding et al., 2021; Luo et al., 2022). The gene discussed is VDR; the disease is neurodegenerative disease.