To further examine how intestinal VDR contributes to the barrier function and protects against carcinogenesis, Zhang et al. utilized azoxymethane/dextran sulfate sodium-induced cancer model in intestinal VDR conditional knockout (VDR∆IEC) mice, 2D and 3D cell cultures, and human colon cancer samples. The gene discussed is VDR; the disease is malignant colon neoplasm.