A meta-analysis found that depression is associated with concurrent and future inflammation in children and adolescents (Colasanto et al., 2020), Similarly, depressed patients were confirmed to have greater levels of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1, IL-4, IL-5, IL-12, interferon-γ (IFN-γ), and C-reactive protein (CRP) in their blood (Hussain et al., 2016), while antidepressant treatment significantly could reduce peripheral levels of IL-6, TNF, IL-10 (Köhler et al., 2018). This evidence concerns the gene TNF and major depressive disorder.