In CUMS-induced depressed mice, the synthesis of peroxides such as MDA increased and the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) decreased (Cheng et al., 2018), and antidepressant drugs could increase the levels of antioxidant enzymes, including catalase (CAT), SOD, and GSH-Px, in depressed patients or animals (Sherkawy et al., 2018; Meejuru et al., 2021; Mishra et al., 2021), the above suggests that improving the oxidative stress state might be an important direction for the treatment of depression. This evidence concerns the gene SOD1 and major depressive disorder.