CREB1 and major depressive disorder: Moreover, in de-ovulated model mice, the detection of CREB and eukaryotic translation elongation factor 2 (eEF2) suggested that Ber (10 mg/kg) can improve depression through the BDNF/CREB/eEF2 pathway, and the onset of action is 2–4 weeks faster than SSRI (Fan et al., 2017).