Transcriptome analysis using RNA-seq revealed that molecular signals such as IL-1β, IL-6, TNF, IκB–NF-κB, TLR, MAPK (involving ERK1/2 and JNK), and apoptosis were intensified in COPD mice compared with controls but weakened in the QJHTD group versus the model group. Here, IL1B is linked to chronic obstructive pulmonary disease.