DNA2 and amyotrophic lateral sclerosis: iNeurons were differentiated from three ALS patients carrying a pathogenic C9ORF72 mutation and three unaffected, age and sex matched controls (STAR Methods: ‘iNPC tissue culture, iNeuron differentiation and DNA2 inhibitor treatment’,Supplementary Table 16). Mirroring our WGS analysis, mtCN was elevated in diseased iNeurons compared to control iNeurons (p = 0.04, Welch's t-test, Fig. 4A, STAR Methods: ‘DNA extraction and mtDNA quantification for iNeurons’) in keeping with a compensation for disease.