Interestingly, ANXA1, a marker relevant to the GBM-GAA crosstalk, is similarly upregulated in GBM – microglia co-culture or the triculture (1.81-, 1.67- and 1.8-fold, respectively), indicating that ANXA1 is a marker for a general activated GBM stroma [39]. This evidence concerns the gene ANXA1 and glioblastoma.