Taken together, they found that ADAM28 is overexpressed in its activated form within human BC tissues by tumor cells and claim that ADAM28 is implicated in cell proliferation via increased bioavailability of IGF-I, which is released from the complex of IGF-I/IGFBP-3 by selective IGFBP-3 cleavage [21]. The gene discussed is IGFBP3; the disease is breast cancer.