BCL2 and adenocarcinoma: In a previous paper [18] we demonstrated that the 7-mer PNA sequence complementary to the longest loop of the G-quadruplex structure formed by the bcl2midG4 DNA sequence located in the P1 promoter of the Bcl-2 proto-oncogene was capable of downregulating the expression of Bcl-2 protein in A549 and MDA-MB-436 adenocarcinoma cells when complexed with an oncolytic adenovirus used as the PNA vector, thus exerting a synergistic anticancer outcome.