In addition, the fact that TF-PNA1K is not released from the heterotriplex complex at temperatures lower than 40 °C at the acidic pH mimicking the one found in cancer cells microenvironment [54] supports the potential applicability of triplex-forming PNAs in the development of novel anti-Bcl-2 anticancer agents utilizable at the physiological body temperature. Here, TF is linked to cancer.