That the hyperphosphorylation of tau contributes to neurodegeneration is well established.32 Mounting evidence suggests tau phosphorylation to contribute to seizures and epilepsy.33 Of note, tau hyperphosphorylation is also a known sign of brain ageing.16 Whether tau phosphorylation is a causative factor of how the lack of the immunoproteasome contributes to neurological deficits or is a consequence of immunoproteasome-induced pathology, however, remains to be determined via, for example, the use of tau-deficient mice. Here, MAPT is linked to epilepsy.