Conversely, when we treated hypothyroidism as an exposure factor, we detected a causal association between hypothyroidism and 13 inflammatory cytokines (IL-13, IL-16, IL-2rα, IL-6, IL-7, IL-9, G-CSF, SCGF-β, IP-10, MIG, MIP-1β, SDF-1α, and TNF-α). This evidence concerns the gene IL2RA and hypothyroidism.