In autoimmune hypothyroidism tissue samples, gene expression of IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-15, IL-16, IL-18, IFN-γ, TNFα, and some chemokines has been observed (32–35). This evidence concerns the gene IL18 and Hashimoto thyroiditis.