TIMP2 and cancer: This cascade of events leads to the upregulation of tissue inhibitor of metalloproteinase-2 (TIMP2), which acts to prevent breakdown of the extracellular matrix, and inactivation of matrix metalloproteinase-2 (MMP2), a zinc-dependent endopeptidase that acts to promote cancer progression by facilitating tumor to form metastases, and the regulation of TIMP2 and MMP2 contributes to the inhibition of bladder cancer invasion (100).