(8),during the investigation of the diagnostic potential of basal luteinizing hormone in central precocious puberty, it was noted that a baseline LH value greater than 0.535 mIU/L could serve as a reliable marker for CPP diagnosis, with a sensitivity of 68.9% and specificity of 86.0%, obviating the need for a GnRH stimulation test to confirm CPP. This evidence concerns the gene PLOD1 and precocious puberty.