HER1–rs11543848 risk allele A (odds ratio [OR] = 2.7705, 95% confidence interval [CI] = 1.9830–3.8706, p = 0.0001) and heterozygous genotype GA (OR = 3.42, 95% CI = 2.1459–5.4506, p = 0.0001) displayed highly significant association with breast cancer, while the homozygous genotype AA showed association but nonsignificant results (OR = 2.637, 95% CI = 1.2258–5.6756, p = 0.0833). The gene discussed is EGFR; the disease is breast cancer.