Specifically, the risk allele A of HER1–rs11543848 (OR = 2.7705, 95% CI = 1.9830–3.8706, p = 0.0001) and the heterozygous genotype GA (OR = 3.42, 95% CI = 2.1459–5.4506, p = 0.0001) exhibited a notably significant association with breast cancer. This evidence concerns the gene EGFR and breast cancer.