In concordance with our findings, maintenance of impulse control has also been associated with preservation of the LC-norepinephrine system independent of tau pathology in AD [71].An additional unexpected finding was the lack of effects between amygdala p-tau severity and neurobehavioral scores despite the known association between amygdala neurodegeneration and agitation and aggression in AD [56]. The gene discussed is MAPT; the disease is Alzheimer disease.