ESR1 and breast cancer: To probe the potential biological significance of DHT-induced AR/GATA3 chromatin binding events, we integrated ChIP-seq data (Figs. 2 and 3; Additional file 2: Figs S2-3) with RNA-seq data we generated from ER+ and ER- breast cancer cell lines stimulated with DHT to identify androgen-regulated AR-GATA3 binding sites associated with differentially expressed genes.