PLA-detected interactions between AR and GATA3 were also evident in clinical primary ER+ /AR + (n = 2 cases) and ER- /AR + (n = 2 cases) breast cancers as well as non-malignant breast tissues from reduction mammoplasties (n = 2 cases) (Fig. 1G; Additional file 2: Fig. S1G, H). The gene discussed is ESR1; the disease is breast cancer.