NicheNet analysis revealed that IL1B, overexpressed in asthmatic Int Macro, was a prioritized ligand for macrophages to interact with fibroblast subpopulations whose prominent target genes (e.g., CCL11, IGF1 and CXCL12) involved in immune response and regulation of neutrophil functions were significantly up-regulated in asthma. This evidence concerns the gene IL1B and asthma.