Among all the MYH11 + COL1A1 + stromal cells, we observed a significant increase in the cell proportion of Myo/SMC and VSMC in AS compared to NC (Fisher’s exact test, FDR < 0.05), suggesting an abnormal increase of myofibroblast and VSMC associated with the pathology of asthma. Here, COL1A1 is linked to asthma.