High CD47 expression was significantly associated with multiple high-risk clinicopathological and genomic characteristics including advanced FIGO stage (p < 0.001), high preoperative serum CA125 and HE4 value (p = 0.002, p = 0.013), presence of multidisciplinary surgeries (p < 0.001), presence and massive volume of ascites (p = 0.003, p < 0.001), positive lymph-node metastasis (p < 0.001), positive Ki-67 index (p = 0.002), and pathogenic TP53 mutation (p = 0.001). The gene discussed is TP53; the disease is metastatic malignant neoplasm in the lymph nodes.