In vivo evidence for microglial ferroptotic stress includes elevation of the microglial-specific lipoxygenases in sporadic ALS-affected tissue (Fig. 1) and ALS model mice (Fig. 5), and microglial-specific elevation of the widely expressed ferroptosis marker LPCAT3 in ALS model mice (Fig. 5k-n). Here, LPCAT3 is linked to amyotrophic lateral sclerosis.