In a GWAS meta-analysis of stroke in > 22,000 individuals of African ancestry undertaken by the Consortium of Minority Population GWAS of Stroke (COMPASS)) (physician-adjudicated stroke patients = 3734 and no history of stroke = 18317), one single-nucleotide polymorphism (SNP rs55931441) near the HNF1A gene attained genomic significance, while variants in 24 additional unique loci including the SFXN4 and TMEM108 genes demonstrated suggestive associations [8]. The gene discussed is TMEM108; the disease is Stroke.