4I). Interestingly, we found that the frequency of both groups of clusters was highest in the 170-infected animals at 4 weeks post-infection (Additional file 1: Fig. S8). Thus, Scriabin revealed the concomitant use of opposing signaling modalities between CD14 monocytes and CD8 TEM cells in response to highly pathogenic Lentivirus infection, underscoring the utility of using single-cell resolution CCC methods to capture the full structure of CCC phenotypes. Here, CD8A is linked to lentivirus infection.