Consequently, these results demonstrate that the activation of the FAK/ERK/AP-1 signalling pathway and the EMT/FMT transition generates increased expression of proinflammatory/profibrotic markers involved in pulmonary vascular remodelling, pulmonary and cardiac fibrosis, left ventricular hypertrophy and increased blood pressure. Here, PTK2 is linked to left ventricular hypertrophy.