Moreover, a key modulator of the transcriptional response to hypoxic stress, HIF1α can also undergo Kla when lactate imported into prostate cancer (PCa) cells via MCT1, which can stabilize HIF1α under normal hypoxic conditions, enhance KIAA1199 transcription and promote angiogenesis in PCa [31]. The gene discussed is HIF1A; the disease is Familial prostate cancer.