Gu et al. demonstrated that lactate can facilitate the Kla of MOESIN at K72 residue to regulate the development and immunosuppressive function of Treg cells, and HCC patients who responded to anti-PD-1 treatment have lower MOESIN Kla levels in Treg cells than nonresponding patients [33]. The gene discussed is KL; the disease is hepatocellular carcinoma.