METTL3 and malignant colon neoplasm: For instance, Xiong et al. demonstrated that lactate accumulated in TME potently up-regulate the expression of METTL3 in tumor-filtrating myeloid cells via H3K18la and increased expression of METTL3 in this cell population was correlated with the poor prognosis among patients of colon cancer, whereas myeloid deficiency of METTL3 can attenuate tumor progression and the immunosuppression of TME.