The expression levels of three writers (DNMT1, DNMT3A, DNMT3B), two erasers (TET1, TET3), and eight readers (MBD4, ZBTB33, UHRF1, UHRF2, UNG, TDG, NTHL1, SMUG1) were dramatically higher in tumor tissues (p < 0.05). Here, SMUG1 is linked to neoplasm.