In the present study, OBP-702 induced ATP more strongly than 5-FU, GEM, nab-PTX, and OXA, and OBP-301, which suggested that OBP-702 was an oncolytic adenovirus possessing a high potential to strongly activate anti-tumor immunity, and p53 played an important role in that mechanism. The gene discussed is TP53; the disease is neoplasm.