CD8A and neoplasm: Dense type I collagen matrix has been shown to slow the migratory capacity of T cells, reduce tumor mass infiltration, and counteract the killing activity of CD8+ cytotoxic-T and NK cells (Hartmann et al, 2014; Rygiel et al, 2011; Hörner et al, 2019; Nicolas-Boluda et al, 2021; Tabdanov et al, 2021; Kuczek et al, 2019; Sun et al, 2021).