Since several other components of the immune system are retained in these mice, immunohistochemistry analyses for the antigen presenting cell (APC) marker MHC-II, macrophages marker Iba1, B-cell marker CD45R (B220), and natural killer (NK) marker NKp46 were performed to investigate the possible role TRPM8/TLR3/NF-kB circuit in anti-cancer immunity. This evidence concerns the gene TLR3 and cancer.