Based on previous literature and our recent work, TRPM8 expression characterizes the luminal compartment of the prostate epithelium in mammals, showing different levels of correlation with the expression of classical androgen target genes such as TMPRSS2, KLK2, NKX3.1, and KLK3 both in normal tissue and in hormone naive prostate cancer (PCa) (Alaimo et al, 2020; Genovesi et al, 2022; Lunardi et al, 2021). Here, TMPRSS2 is linked to posterior cortical atrophy.