STXBP1 and Encephalopathy: Consistent with a major role of saturated FFAs in learning and memory, we also found that haploinsufficient STXBP1 mice have greatly reduced saturated FFAs which may potentially explain their poor cognitive performance (Chen et al, 2020) and that of STXBP1 encephalopathy patients (Abramov et al, 2021; Lanoue et al, 2019; Stamberger et al, 2016).