These results suggest that the DDHD2 KO drives a progressive decline in motor function in mice beginning from 5mo, which further corroborates previous reports suggesting that the ablation of the DDHD2 gene elicits the manifestation of HSP and its associated neuromotor dysfunction symptoms (Blackstone, 2018; Murala et al, 2021). This evidence concerns the gene DDHD2 and hereditary spastic paraplegia.