STXBP1 and Encephalopathy: The role of STXBP1 in neuronal FFA metabolism was further demonstrated by the reduction of FFA levels in STXBP1 knockout neurosecretory cell lines and across the brains of heterozygous STXBP1 knockout mice which is a model of STXBP1 encephalopathy (Chen et al, 2020).