Having demonstrated that DDHD2 knockout mice exhibit cognitive impairment in a specific instrumental learning paradigm that correlated to their lack of saturated FFAs, we therefore further investigated the impact of DDHD2 KO on cognition and neuromuscular function by carrying out a longitudinal assessment (3mo to 12mo) of the age of onset and progression of these deficits. The gene discussed is DDHD2; the disease is Cognitive impairment.