The impairment of memory performance associated with the DDHD2 knockout reported in our study could, at least in part, explain the intellectual disability associated with HSP, and recent studies showing that ablation of the DDHD2 gene alters neural processing (Inloes et al, 2014; Joensuu et al, 2020b; Richmond and Smith, 2011) also strongly advocate for the significant impact of saturated FFAs in synaptic function and plasticity. The gene discussed is DDHD2; the disease is Intellectual disability.