We used a genetically distinct haploinsufficient mouse model (STXBP1+/−) showing a 40–50% decrease in the levels of STXBP1 protein, which recapitulates the cognitive, motor, seizure, and psychiatric phenotypic hallmarks of human encephalopathy (Abramov et al, 2021; Chen et al, 2020). Here, STXBP1 is linked to Encephalopathy.