The importance of phospholipases in this process is exemplified in hereditary spastic paraplegia (HSP; Strümpell-Lorrain disease) in which a mutation in the DDHD2 gene of phospholipase A1 (PLA1) is associated with neuromuscular and cognitive dysfunction (Akefe, 2022; Alrayes et al, 2015; Inloes et al, 2014; Joensuu et al, 2020b; Murala et al, 2021), autism (Matoba et al, 2020), schizophrenia (Park et al, 2021), intellectual disability (Alrayes et al, 2015), and mental retardation (Alrayes et al, 2015; Darios et al, 2020; Inloes et al, 2014; Joensuu et al, 2020b). This evidence concerns the gene DDHD2 and Intellectual disability.