Overlapping the DEGs from both comparisons, SLE compared to control serum and IFN-α+serum compared to IFN-α+serum+anifrolumab, showed only a small overlap of almost exclusively IFN-related genes highlighting the unique response of the organoids to SLE serum (Fig. EV3G). The gene discussed is IFNA2; the disease is systemic lupus erythematosus.