We could observe the significantly elevated level of IL-18 and the presence of IL-6 in almost all SLE, but not control serum samples (Fig. 2G), as it has been reported for bigger SLE cohorts (Ohl and Tenbrock, 2011; Guimarães et al, 2017; Mende et al, 2018; Kulkarni et al, 2007; Živković et al, 2018). Here, IL18 is linked to systemic lupus erythematosus.