Again, comparisons of differential gene expression within the “Immune and Inflammatory response” GO group showed significantly better correlation than the comparisons of global differential gene expression profiles, underscoring the major role of inflammation in shaping the common features of disease phenotype in Spink5 cKO mice, NS, psoriasis and AD patients (Supplementary Fig. 6j, k and Supplementary Data 2). This evidence concerns the gene SPINK5 and psoriasis.