Since KLK14 can cleave AHSG, KLK14 and AHSG are expressed in/near hair follicles75,78, and transgenic mice over-expressing human KLK14 in the epidermis display prominent alopecia phenotype31, KLK14-mediated degradation of AHSG might be involved in alopecia in NS. The gene discussed is AHSG; the disease is alopecia.